Benzothiophene carboxamide derivatives as novel antimalarials
نویسندگان
چکیده
منابع مشابه
Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners.
Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes. Here, we report on the efficacy of aminoquinolines coupled to benzothiophene and thiophene rings in inhibiting Plasmodium falciparum parasite growth. Synthesized compounds were evaluated for their antimalarial activity and toxicity, in vitro a...
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Benzothiophene carboxamide derivatives of aminobenzophenone, aminopyridine, aminobenzimidazole, and aniline derivatives (compounds 1-9) were synthesized and compounds 3, 6, 7, 8, and 9 tested in vivo for their hypolipidemic activity. Compounds 1-8 were prepared adopting the fusion process at 130-150 degrees C between benzothiophene-2-carbonyl chloride and aminobenzophenones, aminopyridine, and ...
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Attempting to produce cyclized systems with potential anti-proliferative activity, a series of novel thiophene and benzothiophene derivatives were designed and synthesized. The reactivity of the latter derivatives towards different chemical reagents was studied. Twenty-one compounds were synthesized and evaluated as anti-cancer agents. The results showed that ethyl 5-amino-3-(4-chlorostyryl)-4-...
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Emergence of new infectious diseases such as tuberculosis, bacterial and fungal diseases have stimulated public interest and inspired commitments by medicinal chemists to control these diseases. Increasing microbial resistance has become a very serious clinical problem for many classes of antibiotics. Therefore, it is an urgent requirement to design and synthesize novel antimicrobial agents to ...
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In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat cortical neuronal cells and in vitro cell-free bioassays. Based on our primary screening data with eighteen synthesized derivatives, nine compounds (1a, 1c,...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2011
ISSN: 1521-6543
DOI: 10.1002/iub.543